Further to above, I was able to obtain a copy of " A History of the County of Antigonish, Nova Scotia" by Rev. D. J. Rankin.
In the Chisholm section, pg. 115 "Chisholm (Buidhe)", it notes "Margaret (Chisholm), was married to Colin MacDonald, of Merigomish, with issue: John, Married to Kate Wall, of Margaree..."
I was also able to find a marriage record for Colin MacDonald and Margaret Chisholm. It notes Colin as being a merchant / Knoydart - born in Merigomish, and his parents being John and Janet McDonald.
I found a cemetery transcription for the Roman Catholic Cemetery, Merigomish (Rootsweb). There is a burial for Collin McDonald d. 1891. I don't have a death date for the Colin I am looking for but I know his wife moved with their children to Glace Bay (she is buried there).
There is also a transcription for John McDonald (no dates) with wife, Janet d. 1870 64 years at this cemetery.
Looking for any information on the parents of Colin McDonald: John McDonald and Janet McDonald (nee ?), likely of Merigomish.